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5177558 
Journal Article 
Short-step synthesis of 1,3-disubstituted naphtho 2,3-c furan-4,9-dione and naphtho 2,3-b furan-4,9-dione by the Friedel-Crafts reaction 
Koyama, J; Toyokuni, I; Kino, A; Tagahara, K 
1998 
Yes 
Heterocycles
ISSN: 0385-5414 
PERGAMON-ELSEVIER SCIENCE LTD 
OXFORD 
48 
8 
1631-1638 
English 
WOS:000075542500014 
1,3-Dialkylnaphtho[2,3-c] furan-4,9-diones were obtained by the Friedel-Crafts reaction of phthalic anhydride with 2,5-dialkylfurans. The reaction of phthalic anhydride with 2-acetyl-5-methylfuran, instead of 2,5-dialkylfurans, produced 2-methylnaphtho[2,3-b] furan-4,9-dione. The application of this method to the synthesis of 8-hydroxynaphtho [2, 3-b] furan-4, 9-dione [isodiodantunezone] is also described. 
Polymer Science; barr-virus-activation, cyto-toxic quinones, agents