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5177968 
Journal Article 
An example of quality control of fine chemical intermediates: related impurity analysis of industrial phthalic anhydride by reversed-phase high-performance liquid chromatography 
Zhou, LF; Qiao, JQ; Lian, HZ; Ge, X 
2011 
1 
Research on Chemical Intermediates
ISSN: 0922-6168
EISSN: 1568-5675 
SPRINGER 
DORDRECHT 
37 
6 
617-625 
English 
WOS:000292987000006 
A reliable reversed-phase high-performance liquid chromatographic method has been developed for analysis of related impurities in industrial phthalic anhydride (PA). Maleic acid (hydrolysis product of maleic anhydride), phthalimide, and benzoic acid were separated from phthalic acid (Pa, hydrolysis product of PA) on a C(18) column by gradient elution with acetonitrile and 0.1% (v/v) aqueous perchloric acid solution. This method is simple, sensitive, and accurate, and has been successfully applied to quality control of PA for industrial use. 
Chemistry; Fine chemicals, Phthalic anhydride, Related impurities, HPLC; organic-acid anhydrides, o-xylene, oxidation, hydrolysis, catalyst, hplc