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5178463 
Journal Article 
One-step synthesis of thalidomide and its important derivatives 
Yuan, XH; Guo, HQ; Qiu, XP; Kang, CQ; Liu, XD; Gao, LX 
2005 
1 
Gaodeng Xuexiao Huaxue Xuebao / Chemical Journal of Chinese Universities
ISSN: 0251-0790 
26 
8 
1477-1479 
Chinese 
WOS:000231321400023 
Thalidomide and its derivatives have great potentials in immune therapy. This research note presented that heating the mixture of phthalic anhydride or its chloro or nitro I substituted derivatives and L-glutamine in vacuum afforded thalidomide 1 and its corresponding derivatives 2-5 directly in yields 24%-47%. Among them, compound 4 is the material in the synthesis of 3-amino and 3-amino-3'-fluoro substituted thalidomide. Compared with traditional methods, this method is more direct and convenient. 
Chemistry; thalidomide, derivatives, one-step method, synthesis; analogs