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5184575 
Journal Article 
A practical large scale synthesis of nimesulide - A step ahead 
Prasad, A; Sharma, ML; Kanwal, S; Rathee, R; Sharma, SD 
2005 
Yes 
Journal of Scientific and Industrial Research
ISSN: 0022-4456 
64 
10 
756-760 
English 
WOS:000232406100006 
Nimesulide, a COX-2 selective drug, possesses anti-inflammatory and analgesic properties. Moreover, it has low gastro-intestinal and renal toxicity. This paper presents industrially viable, new and improved synthesis of nimesulide starting from o-chloro nitrobenzene. The reaction with triphenyl phosphate yields 2-phenoxy nitrobenzene (90%) followed by reduction and mesylation and finally selective nitration furnishes the drug (85%). 
nimesulide; large-scale synthesis; COX-2 selective drug