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5189484 
Journal Article 
Effect of endosulfan and malathion on the ovarian steroidogenesis and brain acetylcholinesterase activity of the catfish, Clarias batrachus (Linnaeus) 
Das, RC; Sengupta, B 
1993 
1 
Veterinarski Arhiv
ISSN: 0372-5480 
63 
2 
75-83 
English 
BIOSIS COPYRIGHT: BIOL ABS. The effect of sublethal concentrations of endosulfan (organochloride insecticide) and malathion (organophosphorus insecticide) was investigated in the catfish, Clarias batrachus. Ovarian DELTA5-3beta-hidroxysteroid dehydrogenase (DELTA5-3beta-HDS) and glucose-6-phosphate dehydrogenase (G-6-PD) and brain acetylcholinesterase (AchE) activities were studied. Endosulfan- and malathion-treated fish ovaries showed the loss of stage-II and III oocytes and the absence of DELTA5-3beta-HDS and G-6-PD acti confirmed the inhibition of steroidogenesis. Malathion demonstrated a dose-dependent inhibition of the brain AchE activity, whereas endosulfan caused no significant reduction of AchE.