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2826280 
Journal Article 
Pesticides as inducers of hepatic drug-metabolizing enzymes-I. Mixed function oxidase activity 
Fabacher, DL; Kulkarni, AP; Hodgson, E 
1980 
Yes 
General Pharmacology
ISSN: 0306-3623
EISSN: 1879-0011 
11 
5 
429-435 
English 
7419035 
WOS:A1980KJ78000004 
is related to other part(s) 8482359 Pesticides as inducers of hepatic drug-metabolizing enzymes-II. Glutathione S-transferases
1. Sixteen pesticides, one carcinogen (3-methylcholanthrene), one cotton defoliant, two drugs (phenobarbital and chloral hydrate) and two insecticide synergists (piperonyl butoxide and sesamex) were administered to adult male mice by different routes in order to evaluate the inductive effects of pesticides on hepatic drug metabolizing enzymes.

2. Of the experimental insecticides screened, TH-6042 (a substituted pyrazoline) showed the highest level of induction of cytochrome P-450 (>3-fold) and also significant increases in O-demethylation of p-nitroanisole and N-demethylation of aminopyrine.

3. Maximum induction was generally achieved when compounds were administered orally for each of 3 days.