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5190230 
Technical Report 
Endosulfan-induced neurotoxicity in rats and mice 
Gupta, PK 
1976 
Yes 
Bulletin of Environmental Contamination and Toxicology
ISSN: 0007-4861
EISSN: 1432-0800 
Springer-Verlag 
15 
6 
708-713 
English 
938763 
WOS:A1976BY30800011 
PESTAB. Adult male and female ITRC rats and mice were injected i.p. with varying amounts of endosulfan dissolved in different vehicles. Rats were more resistant than mice and males were more resistant than females to the toxic effects of endosulfan. In both species, the LD50 for endosulfan in alcohol was about 50% less than that of endosulfan in ground nut oil. Signs of intoxication included hyperresponsiveness to tactile stimuli, tremors in the forelimbs and later throughout the body, and increased respiration followed by respiratory depression. At a single dose of endosulfan, the time until death and severity of symptoms in the rats varied from animal to animal. No definite gross pathological lesions were observed in any of the animals. At 60 mg/kg, endosulfan significantly decreased the brain acetylcholinesterase activity in the female rats.