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HERO ID
5190230
Reference Type
Technical Report
Title
Endosulfan-induced neurotoxicity in rats and mice
Author(s)
Gupta, PK
Year
1976
Is Peer Reviewed?
Yes
Journal
Bulletin of Environmental Contamination and Toxicology
ISSN:
0007-4861
EISSN:
1432-0800
Publisher
Springer-Verlag
Volume
15
Issue
6
Page Numbers
708-713
Language
English
PMID
938763
DOI
10.1007/BF01685621
Web of Science Id
WOS:A1976BY30800011
Abstract
PESTAB. Adult male and female ITRC rats and mice were injected i.p. with varying amounts of endosulfan dissolved in different vehicles. Rats were more resistant than mice and males were more resistant than females to the toxic effects of endosulfan. In both species, the LD50 for endosulfan in alcohol was about 50% less than that of endosulfan in ground nut oil. Signs of intoxication included hyperresponsiveness to tactile stimuli, tremors in the forelimbs and later throughout the body, and increased respiration followed by respiratory depression. At a single dose of endosulfan, the time until death and severity of symptoms in the rats varied from animal to animal. No definite gross pathological lesions were observed in any of the animals. At 60 mg/kg, endosulfan significantly decreased the brain acetylcholinesterase activity in the female rats.
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