Studies of the penetration of native collagen, collagen alpha chains, and collagen cyanogen bromide peptides through hairless mouse skin in vitro | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

5194069

Reference Type

Journal Article

Title

Studies of the penetration of native collagen, collagen alpha chains, and collagen cyanogen bromide peptides through hairless mouse skin in vitro

Author(s)

Coapman, SD; Lichtin, JL; Sakr, A; Schiltz, JR

Year

1988

Is Peer Reviewed?

Journal

Journal of the Society of Cosmetic Chemists
ISSN: 0037-9832

Volume

Issue

Sep-Oct 1

Language

English

Abstract

IPA COPYRIGHT: ASHP The results of experiments assessing the ability of radioactively labeled native collagen, collagen alpha 1(I) chain subunits, and cyanogen bromide peptides derived from alpha 1(I) chains to penetrate hairless mouse skin in vitro are reported. It was concluded that none of the collagen types penetrate intact mouse skin, although limited penetration of cyanogen bromide peptides does occur in skin lacking stratum corneum. Furthermore, experiments which purport to demonstrate penetration of native collagen using preparations labeled with radioactive ligands should be accompanied by demonstrations that the labeled material which penetrates into the dermis has been unchanged.