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HERO ID
5196623
Reference Type
Journal Article
Title
Mechanisms of resistance to insecticides targeting RDL GABA receptors in planthoppers
Author(s)
Nakao, T
Year
2017
Is Peer Reviewed?
1
Journal
NeuroToxicology
ISSN:
0161-813X
EISSN:
1872-9711
Publisher
ELSEVIER SCIENCE BV
Location
AMSTERDAM
Volume
60
Page Numbers
293-298
Language
English
PMID
27000517
DOI
10.1016/j.neuro.2016.03.009
Web of Science Id
WOS:000403133600035
URL
https://linkinghub.elsevier.com/retrieve/pii/S0161813X1630033X
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Abstract
Lindane and cyclodienes, such as dieldrin and α-endosulfan, represent the first generation of noncompetitive antagonists (NCAs) against the insect RDL GABA receptor. It has been reported that A2'S and A2'G mutations in the membrane-spanning region M2 of the RDL GABA receptor confer resistance to lindane and cyclodienes. Fipronil is a second-generation NCA, but A2'S and A2'G mutations provide a low level of cross-resistance to fipronil. Moreover, a novel A2'N mutation that confers fipronil resistance was found in M2 of the RDL GABA receptors from fipronil-resistant planthoppers in the heterozygous state. Thus, problems are being caused by a worldwide appearance of cyclodiene-resistant pests. And attention must be paid to development of fipronil-resistant planthoppers, such as Sogatella furcifera and Laodelphax striatellus in Japan.
Keywords
Cyclodiene resistance; Fipronil resistance; RDL GABA receptor
Conference Name
Symposium on Insecticide Action on Ion Channels - A Tribut to Toshio Narahashi as part of the 15th National Meeting of the Division-of-Agrochemicals of the American-Chemical-Society
Conference Location
Boston, MA
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