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5196623 
Journal Article 
Mechanisms of resistance to insecticides targeting RDL GABA receptors in planthoppers 
Nakao, T 
2017 
1 
NeuroToxicology
ISSN: 0161-813X
EISSN: 1872-9711 
ELSEVIER SCIENCE BV 
AMSTERDAM 
60 
293-298 
English 
27000517 
WOS:000403133600035 
Lindane and cyclodienes, such as dieldrin and α-endosulfan, represent the first generation of noncompetitive antagonists (NCAs) against the insect RDL GABA receptor. It has been reported that A2'S and A2'G mutations in the membrane-spanning region M2 of the RDL GABA receptor confer resistance to lindane and cyclodienes. Fipronil is a second-generation NCA, but A2'S and A2'G mutations provide a low level of cross-resistance to fipronil. Moreover, a novel A2'N mutation that confers fipronil resistance was found in M2 of the RDL GABA receptors from fipronil-resistant planthoppers in the heterozygous state. Thus, problems are being caused by a worldwide appearance of cyclodiene-resistant pests. And attention must be paid to development of fipronil-resistant planthoppers, such as Sogatella furcifera and Laodelphax striatellus in Japan. 
Cyclodiene resistance; Fipronil resistance; RDL GABA receptor 
Symposium on Insecticide Action on Ion Channels - A Tribut to Toshio Narahashi as part of the 15th National Meeting of the Division-of-Agrochemicals of the American-Chemical-Society 
Boston, MA