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HERO ID
520012
Reference Type
Journal Article
Title
Gastric antral vascular ectasia (GAVE): An update on clinical presentation, pathophysiology and treatment
Author(s)
Selinger, CP; Ang, YS
Year
2008
Is Peer Reviewed?
Yes
Journal
Digestion
ISSN:
0012-2823
EISSN:
1421-9867
Volume
77
Issue
2
Page Numbers
131-137
Language
English
DOI
10.1159/000124339
Web of Science Id
WOS:000254893300010
Abstract
Gastric antral vascular ectasia (GAVE), though a rare disorder, causes up to 4% of non-variceal upper GI bleeding. This paper gives an overview of studies examining clinical presentation and pathophysiology, and reviews the current evidence for invasive and non-invasive treatments. GAVE is often associated with systemic illnesses, such as cirrhosis of the liver, autoimmune connective tissue disorders, bone marrow transplantation and chronic renal failure. The pathophysiological changes leading to GAVE have not been fully explained and remain controversial. Patient presentation varies from chronic iron-deficiency anaemia to heavy acute gastrointestinal bleeding. It is important to differentiate GAVE from portal hypertensive gastropathy as GAVE does not respond to measures reducing portal pressures. Endoscopic ablation (Nd:YAG-laser or argon plasma coagulation) is the first-line treatment of choice. As evidence for pharmacological therapy with oestrogen (and/or progesterone), tranexamic acid or thalidomide stems from case reports only, these should be used if endoscopic measures have failed to stop chronic blood loss. Surgical antrectomy should be reserved for unresponsive cases as it is associated with a high mortality. Ultimately, treatment of the underlying medical co-morbidities may lead to resolution of GAVE. Copyright (C) 2008 S. Karger AG, Basel.
Keywords
gastric antral vascular ectasia; watermelon stomach; chronic GI; bleeding; endoscopic therapy; systematic review; portal hypertensive gastropathy; argon plasma coagulation; watermelon; stomach; estrogen-progesterone; therapeutic options; outlet; obstruction; systemic-sclerosis; cirrhotic-patients; tranexamic acid; laser therapy
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