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520474 
Journal Article 
Tests of platelet function 
Shah, U; Ma, AD 
2007 
0 
Current Opinion in Hematology
ISSN: 1065-6251
EISSN: 1531-7048 
14 
5 
432-437 
English 
WOS:000248781300003 
Purpose of review Platelets play a vital role in the normal hemostasis, and derangements of their function can lead to hemorrhage or thrombosis. While we have made progress in elucidating the molecular mechanisms leading to platelet adhesion, aggregation, shape change, and secretion, clinically useful tests of platelet function have lagged behind. The following is a review of some of the currently available tests of platelet function, their advantages and drawbacks, as well as the clinical scenarios in which they are likely to be useful. Recent findings Attention is now being paid to standardization and optimization of older tests such as platelet aggregometry, in addition to better defining the role of newer tests such as the platelet function analyzer and thromboelastography in diagnosing and managing disorders of primary hemostasis and platelet function. Summary Platelet function is complex and may be disrupted at any of a number of steps, including adhesion, aggregation, shape change and secretion. We are better defining the role of the currently available tests, while identifying gaps in our ability to diagnose disorders of platelet function. 
electron microscopy; flow cytometry; PFA-100; platelet aggregation; platelet function; platelet secretion; impaired primary hemostasis; von-willebrand-disease; bleeding-time; test; plate(let) analyzer; practical concept; p-selectin; blood; thrombelastography; identification; thromboelastography