Novel bridgehead nitrogen heterocyclic systems: Synthesis and antimicrobial activity of imidazo[1,2-d]-s-triazolo [3,4-b][1,3,4]thiadiazoles | Health & Environmental Research Online (HERO)

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HERO ID

5205193

Reference Type

Journal Article

Title

Novel bridgehead nitrogen heterocyclic systems: Synthesis and antimicrobial activity of imidazo[1,2-d]-s-triazolo [3,4-b][1,3,4]thiadiazoles

Author(s)

Mohan, J; Kataria, S

Year

1998

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Journal

Indian Journal of Chemistry. Section B
ISSN: 0376-4699
EISSN: 0975-0983

Volume

Issue

Page Numbers

713-714

Web of Science Id

WOS:000075579700019

URL

http://://WOS:000075579700019
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Abstract

A facile synthesis of 7-aryl-3-ethylimidazo[1,2-d]-s-triazolo[3,4-b][1,3,4]thiadiazole 3 has been achieved by the condensation of 4-amino-3-ethyl-5-mercapto-s-triazole 1 with cyanogen bromide to yield 6-amino-3-ethyl-s-triazolo[3,4-b][1,3,4]thiadiazole 2 followed by treatment with alpha-haloketones. The structures 3 are supported by IR and H-1 NMR spectral data. The antibacterial and antifungal activities of the system have also been evaluated.