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5207145 
Journal Article 
Synthesis of some new 2,5-disubstituted 1,3,4-oxadiazole derivatives and their biological activity 
Khan, MSY; Akhtar, M 
2003 
1 
Indian Journal of Chemistry. Section B
ISSN: 0376-4699
EISSN: 0975-0983 
42 
4 
900-904 
WOS:000182588500008 
2-(Coumarin-3-yl)-5-aryl-1,3,4-oxadiazole derivatives 3-5 have been synthesised by condensing hydrazide 2 of 3-carbethoxycoumarin with various aromatic acids. Compound 3 is also synthesized by another route involving synthesis Of an intermediate N-2-hydroxy benzylidene coumarin-3-carboxyhydrazide 6 which is prepared by reacting 2 with salicylaldehyde, On refluxing it in presence of chloramine T the desired 1,3,4-oxadiazole derivative 3 is obtained. In another set of experiments, 4-methyl-7-(5-phenyl-1,3,4-oxadiazole-2-yl methoxy) coumarin 10 and 4-methyl-7-(5-amino-1,3,4-oxadiazo-2-yl methoxy) cournarin 11 were prepared by condensing 4-methyl coumarinyl-7-oxyacetic hydrazide 9 with benzoic acid and cyanogen bromide respectively. All the oxadiazole derivatives and the compound 6 have been tested for their antiinflammatory, analgesic and antimicrobial activity with interesting results.