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521822 
Journal Article 
Annexin 1: differential expression in tumor and mast cells in human larynx cancer 
Silistino-Souza, R; Rodrigues-Lisoni, FC; Cury, PM; Maniglia, JV; Raposo, LS; Tajara, EH; Christian, HC; Oliani, SM 
2007 
Yes 
International Journal of Cancer
ISSN: 0020-7136
EISSN: 1097-0215 
120 
12 
2582-2589 
English 
Annexin 1 protein (ANXA1) expression was evaluated in tumor and mast cells in human larynx cancer and control epithelium. The effect of the exogenous ANXA1 (peptide Ac 2-26) was also examined during the cellular growth of the Hep-2 human larynx epidermoid carcinoma cell line. This peptide inhibited the proliferation of the Hep-2 cells within 144 hr. In surgical tissue specimens from 20 patients with larynx cancer, ultrastructural immunocytochemistry analysis showed in vivo down-regulation of ANXA1 expression in the tumor and increased in mast cells and Hep-2 cells treated with peptide Ac2-26. Combined in vivo and in vitro analysis demonstrated that ANXA1 plays a regulatory role in laryngeal cancer cell growth. We believe that a better understanding of the regulatory mechanisms of ANXA1 in tumor and mast cells may lead to future biological targets for the therapeutic intervention of human larynx cancer. (c) 2007 Wiley-Liss, Inc. 
human mast cells; Hep-2 cells; annexin 1; larynx tumor; ultrastructural; immunocytochemistry; in-situ hybridization; gastric-cancer; lipocortin-i; carcinoma; dexamethasone; inflammation; apoptosis; growth; a1; angiogenesis