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Journal Article 
Experimental and clinical data for postoperative hyperalgesia mechanisms 
Simonnet, G; Mick, G 
Douleur et Analgesie
ISSN: 1011-288X
EISSN: 1951-6398 
The occurrence of chronic postoperative pain depends on multiple factors, before surgery, during surgery and after it. These factors lead to more or less individual vulnerability, directly linked to the surgery itself but also in a given biographic context and determined environment. Recently, emphasis has been put on reducing nociceptive inputs during acute postoperative pain management, to limit the likelihood of chronic postoperative pain. It seems however that surgical vulnerability is as important as pain management for the optimization of surgical analgesia and the quality of the surgical act. Experimental data support the concept of an implicit memory for previous aggression, predisposing to personal nociceptive hypersensitivity, especially in the context of surgery, particularly if it is post-traumatic or carcinologic. Taking these vulnerability factors into account prompts us to develop new antihyperalgesic strategies based on pharmacological and non-pharmacological alternatives used prior to or just after surgery. 
Hypersensitivity; Hyperalgesia; Postoperative pain; Memory of pain; opioid-induced hyperalgesia; long-lasting hyperalgesia; experienced; rats; pain; tolerance; fentanyl; ketamine; analgesia; sensitization; enhancement