Health & Environmental Research Online (HERO)


Print Feedback Export to File
522762 
Journal Article 
THE ROLE OF COMPLEMENT SYSTEM IN HEMATOPOIESIS 
Slowik-Zylka, D; Poziomkowska-Gesicka, I; Mikolajek-Bedner, W 
2009 
36 
2 
279-294 
Polish 
This review presents the experimental data indicating that complement system plays an important, however, up to now underestimated role in the regulation of hematopoiesis. The cleavage fragments of the third complement component (C3) regulate the response of early hematopoietic cells to an SDF-1 gradient, which is the main chemoattractant for stern cells. Complement system is activated in bone marrow both during myeloablative conditioning for hematopoietic transplantation as well as during pharmacological mobilization of stem cells. Therefore modulation of complement activation may lead to new strategies to accelerate engraftment of stern cells or to increase their mobilization into peripheral blood. 
stromal derived factor-1 (SDF-1); hematopoiesis; CXCR4 receptor; complement system; chemokine receptor cxcr4; stem-cell mobilization; homing-related; responses; human cd34(+) cells; bone-marrow; stem/progenitor cells; component c3; factor-i; peripheral-blood; progenitor cells