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523644 
Journal Article 
A beta(1-42) stimulates adult SVZ neurogenesis through the p75 neurotrophin receptor 
Sotthibundhu, A; Li, QX; Thangnipon, W; Coulson, EJ 
2009 
1 
Neurobiology of Aging
ISSN: 0197-4580
EISSN: 1558-1497 
30 
12 
1975-1985 
English 
The generation of amyloid-beta peptide (A beta) and its accumulation in amyloid plaques are generally recognized as key characteristics of Alzheimer's disease. A number of reports have indicated that A beta can regulate the proliferation of neural precursor cells and adult neurogenesis, suggesting that this may underpin the cognitive decline and compromised olfaction also associated with the condition. Here we report that A beta(1-42) treatment both in vitro and in vivo, as well as endogenous generation of A beta in C 100 and APP/PS1 transgenic models of Alzheimer's disease. stumulate neurogenesis of young adult subventricular zone precursors The neurogenic effect of A beta(1-42) was found to require expression of the p75 neurotrophin receptor (p75(NTR)) by the. precursor cells, and activation of p75(NTR) by metalloprotease cleavage However, precursors from 12-month-old APP/PS1 mice failed to respond to A beta(1-42), Our results suggest that overstunulation of p75(NTR)-positive progenitors during early life might result in depletion of the stein cell pool and thus a more rapid decline in basal neurogenesis. This, in turn, could lead to impaired neurogenic function in later life. (C) 2008 Elsevier Inc All rights reserved 
p75(NTR); Alzheimer's disease; Subventricular zone; Olfaction; Amyloid; Neurosphere; Proteolysis; neural stem-cells; amyloid beta-protein; nerve growth-factor; alzheimers-disease; subventricular zone; mouse model; a-beta; hippocampal neurogenesis; precursor protein; cycle progression