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5242981 
Journal Article 
An improved and green synthesis of N-benzy1-4-formylpiperidine, a key intermediate of donepezil 
Chavakula, R; Karuru, MR; Saladi, CJS; Gouri, VK; Annapurna, N; Babu, RK 
2018 
Yes 
Journal of the Indian Chemical Society
ISSN: 0019-4522 
SCIENTIFIC PUBL-INDIA 
JODHPUR 
95 
10 
1245-1248 
An industrially viable and green synthesis of N-benzy1-4-formylpiperdine (2), a key intermediate of Donepezil hydrochloride (3) (Aricept (R)), a selective inhibitor of acetyl cholinesterase (AChE) and the most promising agent for the treatment of mild to moderate dementia (Alzheimer). We report the synthesis of N-benzy1-4-formylpiperdine (2) by Corey-Kim oxidation of N-benzy1-4-hydroxymethylpiperidine (4) with using odoroless dodecyl methyl sulfide instead of dimethyl sulfide. 
Dementia (Alzheimer); donepezil; Corey-Kim oxidation; odoroless dodecyl methyl sulfide