US EPA

5246165 

Journal Article 

Synthesis of Some New Phenothiazine Derivatives As Memory Enhancers 

Jadhav, NY; Hipparagi, SM; Raju, MB; Surana, Y; Ashok, P 

2017 

Yes 

Indian Journal of Heterocyclic Chemistry
ISSN: 0971-1627 

CONNECT JOURNALS 

GHAZIABAD 

27 

3 

303-309 

English 

WOS:000423272500014 

http://://CCC:000423272500014
Exit
 

There is a need to improve memory in various memory deficits and, therefore, we have synthesized some fused bicyclophenothiazine derivatives having Nootropic activity. Compounds (N1-N7) have been synthesized by treating formaldehyde, aryl amine with 7,8,9 -substituted 1 carboxyl phenothiazine in the presence of hydrochloric acid by Mannich reaction. 2-Carboxy-2', 3' and 4' substituted diphenylamines have been synthesized by the reaction between 2-chlorobenzoic acid with 2,3,4 substituted anilines, respectively, in the presence of anhydrous K2CO3 and CuO by Ullmann reaction. The titled compounds (N8-N15) were synthesized by replacing the starting material 2-chlorobenzoic acid with m-dichlorobenzene/1-chloro-2,4-dinitrobenzene. Synthesized compounds were characterized by spectral data. Compounds N14 and N15 were evaluated for nootropic activity by using Cook's pole climbing apparatus and elevated plus maze model. 

Polymer Science; Mannich, Nootropic, Phenothiazine, Ullmann reaction