Journal Article
Effect of salmon-calcitonin on the analgesic effect of selective mu, delta and kappa opioid agonists in mice
Goicoechea, C; Ormazabal, MJ; Alfaro, MJ; Martin, MI
Neuroscience Letters
ISSN: 0304-3940
EISSN: 1872-7972
The analgesic effect of three different opioid agonists, DAMGO ([D-Ala2,N-Me-Phe4,Gly5-ol]enkephalin), U-50,488H (trans-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidynyl)cyclohexyl] benzene-aceramide methane sulphonate), and [D,Pen2-D,Pen5]-enkephalin, which act upon mu, delta and kappa opioid receptors, respectively, was compared in the presence and absence of salmon-calcitonin (s-CT). The analgesic test used was the writhing test in mice. The analgesic effect of the opioids was significantly enhanced by pretreatment of the animals with s-CT intraperitoneally (i.p.) administered. This effect was more evident for the delta and kappa-agonists. The present result suggests that the joint administration of s-CT and opioids may be a useful and interesting alternative in the treatment of painful diseases resistant to other treatments.
3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide,; (trans)-Isomer/administration & dosage; Analgesics, Non-Narcotic/administration & dosage; Analgesics, Opioid/administration & dosage/pharmacology; Animals; Calcitonin/administration & dosage/pharmacology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins/administration & dosage; Injections, Intraperitoneal; Injections, Intraventricular; Receptors, Opioid/agonists/metabolism; Receptors, Opioid, delta/agonists/metabolism; Receptors, Opioid, kappa/agonists/metabolism; Receptors, Opioid, mu/agonists/metabolism