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526029 
Journal Article 
Review 
Cannabinoid receptors 1 and 2 (CB1 and CB2), their distribution, ligands and functional involvement in nervous system structures - A short review 
Svizenska, I; Dubovy, P; Sulcova, A 
2008 
1 
Pharmacology, Biochemistry and Behavior
ISSN: 0091-3057
EISSN: 1873-5177 
90 
4 
501-511 
English 
In the last 25 years data has grown exponentially dealing with the discovery of the endocannabinoid system consisting of specific cannabinoid receptors, their endogenous ligands, and enzymatic systems of their biosynthesis and degradation. Progress is being made in the development of novel agonists and antagonists with receptor subtype selectivity which should help in providing a greater understanding of the physiological role of the endocannabinoid system and perhaps also in a broad number of pathologies. This could lead to advances with important therapeutic potential of drugs modulating activity of endocannabinoid system as hypnotics, analgesics, antiemetics, antiasthmatics, antihypertensives, immunomodulatory drugs, antiphlogistics, neuroprotective agents, antiepileptics, agents influencing glaucoma, spasticity and other "movement disorders", eating disorders, alcohol withdrawal, hepatic fibrosis, bone growth, and atherosclerosis. The aim of this review is to highlight distribution of the CB I and CB2 receptor subtypes in the nervous system and functional involvement of their specific ligands. (c) 2008 Elsevier Inc. All rights reserved. 
cannabinoid; CB receptors; endocannabinoid system; nervous system; therapeutic potential; in-situ hybridization; fatty-acid amide; rat spinal-cord; stimulus-evoked activity; blastoma cell-membranes; dynamic-range; neurons; endogenous cannabinoids; adenylate-cyclase; messenger-rna; squirrel-monkeys