Genomic imprinting and reproduction
Swales, AKE; Spears, N
HERO ID
526046
Reference Type
Journal Article
Year
2005
Language
English
| HERO ID | 526046 |
|---|---|
| In Press | No |
| Year | 2005 |
| Title | Genomic imprinting and reproduction |
| Authors | Swales, AKE; Spears, N |
| Journal | Reproduction |
| Volume | 130 |
| Issue | 4 |
| Page Numbers | 389-399 |
| Abstract | Genomic imprinting is the parent-of-origin specific gene expression which is a vital mechanism through both development and adult life. One of the key elements of the imprinting mechanism is DNA methylation, controlled by DNA methyltransferase enzymes. Germ cells undergo reprogramming to ensure that sex-specific genomic imprinting is initiated, thus allowing normal embryo development to progress after fertilisation. In some cases, errors in genomic imprinting are embryo lethal while in others they lead to developmental disorders and disease. Recent studies have suggested a link between the use of assisted reproductive techniques and an increase in normally rare imprinting disorders. A greater understanding of the mechanisms of genomic imprinting and the factors that influence them are important in assessing the safety of these techniques. |
| Doi | 10.1530/rep.1.00395 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | beckwith-wiedemann-syndrome; intracytoplasmic sperm injection; dna; methyltransferase expression; paternal methylation imprint; histone; deacetylase complex; in-vitro fertilization; cpg-binding protein-2; germ-cells; transcriptional repression; mammalian development |
| Is Qa | No |