Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
527245
Reference Type
Journal Article
Title
A diagnostic approach to hemochromatosis
Author(s)
Tavill, AS; Adams, PC
Year
2006
Is Peer Reviewed?
Yes
Journal
Canadian Journal of Gastroenterology
ISSN:
0835-7900
Volume
20
Issue
8
Page Numbers
535-540
Language
English
Abstract
In the present clinical review, a diagnostic approach to hemochromatosis is discussed from the perspective of two clinicians with extensive experience in this area. The introduction of genetic testing and large-scale population screening studies have broadened our understanding of the clinical expression of disease and the utility of biochemical iron tests for the detection of disease and for the assessment of disease severity. Liver biopsy has become more of a prognostic test than a diagnostic test. The authors offer a stepwise, diagnostic algorithm based on current evidence-based data, that they regard as most cost-effective. An early diagnosis can lead to phlebotomy therapy to prevent the development of cirrhosis.
Keywords
hemochromatosis; HFE; iron overload; serum ferritin level; long-term survival; hepatic iron index; hereditary hemochromatosis; genetic hemochromatosis; transferrin; saturation; general-population; primary-care; homozygous; hemochromatosis; noninvasive prediction
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity