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527245 
Journal Article 
A diagnostic approach to hemochromatosis 
Tavill, AS; Adams, PC 
2006 
Yes 
Canadian Journal of Gastroenterology
ISSN: 0835-7900 
20 
8 
535-540 
English 
In the present clinical review, a diagnostic approach to hemochromatosis is discussed from the perspective of two clinicians with extensive experience in this area. The introduction of genetic testing and large-scale population screening studies have broadened our understanding of the clinical expression of disease and the utility of biochemical iron tests for the detection of disease and for the assessment of disease severity. Liver biopsy has become more of a prognostic test than a diagnostic test. The authors offer a stepwise, diagnostic algorithm based on current evidence-based data, that they regard as most cost-effective. An early diagnosis can lead to phlebotomy therapy to prevent the development of cirrhosis. 
hemochromatosis; HFE; iron overload; serum ferritin level; long-term survival; hepatic iron index; hereditary hemochromatosis; genetic hemochromatosis; transferrin; saturation; general-population; primary-care; homozygous; hemochromatosis; noninvasive prediction