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527383 
Journal Article 
Recording of high V1-V3 precordial leads may be essential to the diagnosis of Brugada syndrome during the ajmaline test 
Teijeiro, R; Garro, HA; Acunzo, RS; Albino, E; Chiale, PA 
2006 
No 
Journal of Cardiovascular Pharmacology and Therapeutics
ISSN: 1074-2484 
11 
2 
153-155 
English 
Sodium channel-blocking agents are routinely used to unveil the Brugada syndrome in patients in whom the typical electrocardiographic pattern is absent or doubtful. In this article, the authors report a patient with syncopal episodes of unknown origin in whom the conventional electrocardiographic result was normal and a negligibly small "saddle back" type repolarization was present in lead V2 recorded 2 intercostal spaces above the conventional site. Intravenous ajmaline (50 mg) did not elicit the type 1 pattern of the Brugada syndrome in the precordial leads obtained at their usual level, but a clear-cut coved-type repolarization was apparent in high right precordial leads. These findings indicate that high precordial leads should be routinely recorded while assessing the ajmaline test in patients suspected of having the Brugada syndrome. 
Brugada syndrome; precordial electrocardiographic mapping; sodium; channel-blocking agents; st-segment-elevation; death