Health & Environmental Research Online (HERO)


Print Feedback Export to File
5299029 
Journal Article 
Mimicking the biological activity of diazobenzo[b]fluorene natural products with electronically tuned diazofluorene analogs 
Zeng, W; Eric Ballard, T; Tkachenko, AG; Burns, VA; Feldheim, DL; Melander, C 
2006 
Yes 
Bioorganic & Medicinal Chemistry Letters
ISSN: 0960-894X
EISSN: 1464-3405 
16 
19 
5148-5151 
English 
16870443 
WOS:000240615400033 
Under appropriate electronic modulation, simple diazofluorene analogs recapitulate the DNA cleavage activity of kinamycin D under thiol-based reducing conditions. Achieving DNA cleavage under these reducing conditions is key to anticancer activity, as the most active compound, 1-methoxydiazofluorene, inhibits the proliferation of HeLa cells. 
kinamycins; lomaiviticins; DNA cleavage; diazofluorenes; antiproliferative activity