Compatibility study between fluvoxamine maleate, mebeverine hydrochloride and tablet excipients using differential scanning calorimetry | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

5304870

Reference Type

Journal Article

Title

Compatibility study between fluvoxamine maleate, mebeverine hydrochloride and tablet excipients using differential scanning calorimetry

Author(s)

Foda, NH

Year

1992

Is Peer Reviewed?

Yes

Journal

Egyptian Journal of Pharmaceutical Sciences
ISSN: 0301-5068

Volume

Issue

Page Numbers

1-2

Abstract

IPA COPYRIGHT: ASHP The physicochemical compatibility between fluvoxamine maleate, mebeverine hydrochloride, and a number of common tablet and capsule excipients was investigated by differential scanning calorimetry. Mebeverine was incompatible with stearic acid, lactose, sodium carboxymethylcellulose, and corn starch and compatible with cellulose microcrystalline (Avicel PH-101; Elcema G-250), starch (STA-Rx-1500), cottonseed oil hydrogenated (sterotex), povidone (PVP), and magnesium stearate. Fluvoxamine was compatible with starch, PVP, Elcema, sterotex, and Avicel. It was incompatible with stearic acid, magnesium stearate, lactose, and sodium carboxymethylcellulose.