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530524 
Journal Article 
Defining acute renal failure: RIFLE and beyond 
Van Biesen, W; Vanholder, R; Lameire, N 
2006 
Yes 
Journal of the American Society of Nephrology
ISSN: 1046-6673
EISSN: 1533-3450 
1 
6 
1314-1319 
English 
The introduction of the RIFLE classification has increased the conceptual understanding of the acute kidney injury (AKI) syndrome, and this classification has been successfully tested in a number of clinical studies. This review discusses the strengths and weaknesses of the RIFLE classification and suggests additional parameters to broaden future definitions of AKI. These definitions should not only focus on kidney function alone, but also include parameters describing the origin of the patient, the most important causal factors responsible for AKI and information on the pre-existing kidney function. This more complete definition should lead to a decrease in the variability of the results of epidemiological studies and of future clinical trials in AKI populations. 
critically-ill patients; glomerular-filtration-rate; acute kidney; injury; high-volume hemofiltration; serum creatinine; replacement; therapy; cystatin-c; septic shock; hospitalized-patients; cardiac-surgery