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530635 
Journal Article 
Neuroprotective properties and mechanisms of erythropoietin in in vitro and in vivo experimental models for hypoxia/ischemia 
van der Kooij, MA; Groenendaal, F; Kavelaars, A; Heijnen, CJ; van Bel, F 
2008 
Yes 
Brain Research Reviews
ISSN: 0165-0173 
59 
1 
22-33 
English 
Besides its established function in erythropoiesis, erythropoietin (EPO) is currently also appreciated for its neuroprotective effects. The detrimental sequelae of prolonged cerebral hypoxia and ischemia have been shown to attenuate by EPO treatment. After binding to the EPO receptor, EPO is capable of initiating a cascade of events which -via different pathways-may lead to neuroprotection. The circumstances that determine which specific signalling route(s) are activated by EPO are largely unknown. We aim to provide the reader with a timely overview on the use of EPO in models of stroke and hypoxia-ischemia and to discuss the molecular events that underlie its neuroprotection. (C) 2008 Elsevier B.V. All rights reserved. 
Erythropoietin; Hypoxia; Ischemia; Mechanism; Neuroprotection; Review; neonatal hypoxia-ischemia; focal cerebral-ischemia; blood-brain-barrier; dose recombinant erythropoietin; colony-stimulating factor; postnatal day-7 rats; common beta-subunit; nf-kappa-b; neuronal apoptosis; carbamylated erythropoietin