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5310670 
Journal Article 
STILLE CROSS-COUPLING REACTIONS OF ARYL MESYLATES AND TOSYLATES USING A BIARYLPHOSPHINE BASED CATALYST SYSTEM 
Naber, JR; Fors, BP; Wu, X; Gunn, JT; Buchwald, SL 
2010 
Yes 
Heterocycles
ISSN: 0385-5414 
80 
2 
1215-1226 
English 
23596345 
WOS:000276939500045 
A catalyst system for the Stille cross-coupling reactions of aryl mesylates and tosylates is reported. Using the combination of Pd(OAc)2, XPhos, and CsF in t-BuOH an array of aryl and heteroaryl sulfonates were successfully employed in these reactions. Morever, heteroarylstannanes, such as furyl, thiophenyl, and N-methylpyrrole, which are often prone to decomposition, were efficiently coupled under these conditions. Ortho-substitution on the stannane coupling partner was well tolerated; however, the presence of ortho substituents on the aryl sulfonates greatly reduced the proficiency of these reactions. 
Aryl Mesylate; Palladium Catalysis; C-C Bond Formation; Stille Reaction; Aryl Tosylate