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531646 
Journal Article 
Application of a new algorithm in the differential diagnosis of wide QRS complex tachycardia 
Vereckei, A; Duray, G; Szenasi, G; Altemose, GT; Miller, JM 
2007 
Yes 
European Heart Journal
ISSN: 0195-668X
EISSN: 1522-9645 
28 
5 
589-600 
English 
Aims The Brugada criteria proposed to distinguish between regular, monomorphic wide QRS complex tachycardias (WCT) caused by supraventricular (SVT) and ventricular tachycardia (VT) have been reported to have a better sensitivity and specificity than the traditional criteria. By incorporating two new criteria, a new, simplified algorithm was devised and compared with the Brugada criteria. Methods and results A total of 453 WCTs (331 VTs, 105 SVTs, 17 pre-excited tachycardias) from 287 consecutive patients with a proven electrophysiological (EP) diagnosis were prospectively analysed by two of the authors blinded to the EP diagnosis. The following criteria were analysed: (i) presence of AV dissociation; (ii) presence of an initial R wave in lead aVR; (iii) whether the morphology of the WCT correspond to bundle branch or fascicular block; (iv) estimation of initial (v(i)) and terminal (v(t)) ventricular activation velocity ratio (v(i)/v(t)) by measuring the voltage change on the ECG tracing during the initial 40 ms (v(i)) and the terminal 40 ms (v(t)) of the same bi- or multiphasic QRS complex. A v(i)/v(t) > 1 was suggestive of SVT and a v(i)/v(t) < of VT. An initial R wave in lead aVR suggested VT. The overall test accuracy of the new algorithm was superior (P = 0.006) to that of the Brugada criteria. The new algorithm had a greater sensitivity (P < 0.001) and (-) predictive value (NPV) for VT diagnosis, and specificity (P = 0.0471) and (+) predictive value (PPV) for SVT diagnosis than those of the Brugada criteria [both NPV for VT diagnosis and PPV for SVT diagnosis were: 83.5% (95% confidence interval = CI 75.9-91.1%) for the new vs. 65.2% (95% CI 56.5-73.9%) for the Brugada algorithms]. Conclusion The new algorithm is a highly accurate tool for correctly diagnosing the cause of WCT ECGs. 
wide QRS complex tachycardia; brugada criteria; ventricular; tachycardia; supraventricutar tachycardia; bundle-branch-block; fascicular ventricular-tachycardia; electrocardiographic criteria; supraventricular tachycardia; intraventricular-conduction; regular tachycardia; ecg