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5323414 
Journal Article 
Review 
Lubrication in tablet formulations 
Wang, J; Wen, H; Desai, D 
2010 
1 
European Journal of Pharmaceutics and Biopharmaceutics
ISSN: 0939-6411
EISSN: 1873-3441 
75 
1 
1-15 
English 
20096779 
WOS:000278043200001 
Theoretical aspects and practical considerations of lubrication in tablet compression are reviewed in this paper. Properties of the materials that are often used as lubricants, such as magnesium stearate, in tablet dosage form are summarized. The manufacturing process factors that may affect tablet lubrication are discussed. As important as the lubricants in tablet formulations are, their presence can cause some changes to the tablet physical and chemical properties. Furthermore, a detailed review is provided on the methodologies used to characterize lubrication process during tablet compression with relevant process analytical technologies. Finally, the Quality-by-Design considerations for tablet formulation and process development in terms of lubrication are discussed. (C) 2010 Elsevier B.V. All rights reserved. 
Lubrication; Lubricants; Tablet formulation; Tablet compression; Magnesium stearate; Quality-by-Design; Process analytical technology