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532383 
Journal Article 
Dissolution enhancement of fenofibrate by micronization, cogrinding and spray-drying: Comparison with commercial preparations 
Vogt, M; Kunath, K; Dressman, JB 
2008 
1 
European Journal of Pharmaceutics and Biopharmaceutics
ISSN: 0939-6411
EISSN: 1873-3441 
68 
2 
283-288 
English 
17574403 
WOS:000253304700015 
Several techniques were compared for improving the dissolution of fenofibrate, a poorly soluble drug. Particle size reduction was realized by jet milling (micronization; cogrinding with lactose, polyvinylpyrrolidone or sodium lauryl sulphate) and by media milling using a bead mill (nanosizing) with subsequent spray-drying. Solid state characterization by X-ray diffraction and Differential Scanning Calorimetry verified the maintenance of the crystalline state of the drug after dry milling and its conversion to the amorphous state during spray-drying. Micronization of fenofibrate enhanced its dissolution rate in biorelevant media (8.2% in 30 min) compared to crude material (1.3% in 30 min). Coground mixtures of the drug increased the dissolution rate further (up to 20% in 30 min). Supersaturated solutions were generated by nanosizing combined with spray-drying, this process converted fenofibrate to the amorphous state. Fenofibrate drug products commercially available on the German and French markets dissolved similarly to crude or micronized fenofibrate, but significantly slower than the coground or spray-dried fenofibrate mixtures. The results suggest that cogrinding and spray-drying are powerful techniques for the preparation of rapidly dissolving formulations of fenofibrate, and could potentially lead to improvements in the bioavailability of oral fenofibrate products. (c) 2007 Elsevier B.V. All rights reserved. 
biorelevant media; cogrinding; dissolution rate enhancement; fenofibrate; jet milling; micronization; particle size reduction; spray-drying; water-soluble drugs; particle-size; solid dispersion; crystal-growth; polyvinylpyrrolidone; bioavailability; improvement; systems; nanosuspensions; indomethacin