US EPA

5328664 

Journal Article 

Toxicity Of Carbofuran And Lindane To The Old-Field Mouse (Peromyscus Polionotus) And The Cotton Mouse (P. Gossypinus) 

Wolfe, JL; Esher, RJ 

1980 

Yes 

Bulletin of Environmental Contamination and Toxicology
ISSN: 0007-4861
EISSN: 1432-0800 

24 

6 

The toxicity of carbofuran (1563662) and lindane (58899) was investigated in field mice and cotton mice. Dietary concentrations of 0.5, 1.0, 1.5, and 2.0 milligrams lindane per gram food (mg/g) and 1.0mg carbofuran/g food were administered over a 4 day period for the determination of lethal concentrations. Dietary concentrations for 8 month tests of chronic effects were 0.2mg (0.02 percent) lindane/g food and 0.1mg (0.01 percent) carbofuran/g food. Animals were paired and placed on the diet for determining survival, reproduction, and development of young. A residential maze consisting of four arms radiating from a central chamber was used for behavioral tests. Mortality after 96 hours on carbofuran was 20 percent at 0.25mg/g and 100 percent at 0.50mg/g. With lindane, there was no mortality at 0.50mg/g, 50 percent at 1.00mg/g, 80 percent at 1.50mg/g, and 100 percent at 2.00mg/g. Food consumption was normal over the 8 month chronic test period; no significant difference in mortality between treated and test animals was observed. Neither experimental diet had an adverse effect on production. There was no significant effect of either treatment on growth rate of developmental characteristics. No significant differences in behavioral characteristics were observed after chronic treatment for 8 months. The authors conclude that there are no cumulative or delayed effects in production, growth, and development of young, or behavior of mice fed lindane or carbofuran at the concentrations tested.