US EPA

5330204 

Journal Article 

Sex difference in enhancement of gamma-glutamyltranspeptidase-positive foci by hexachlorobenzene and lindane in rat liver 

Pereira, MA; Herren, SL; Britt, AL; Khoury M, MM 

1982 

Yes 

Cancer Letters
ISSN: 0304-3835
EISSN: 1872-7980 

15 

1 

95-102 

HEEP COPYRIGHT: BIOL ABS. (Hexachlorobenzene and lindane (BHC) are fungicides and insecticides that are carcinogenic in mice, producing benign and malignant liver tumors.) The ability of hexachlorobenzene and lindane in diethylnitrosamine (DENA)-pretreated rats to enhance the incidence of gamma-glutamyltranspeptidase (GGTase)-positive foci was determined. In rats that received either DENA followed by a basal agar diet or hexachlorobenzene or lindane without prior administration of DENA, the incidence of GGTase-positive foci was negligible. When hexachlorobenzene or lindane was administered in the diet to rats that previously received DENA, there was an increased incidence of GGTase-positive foci that was greater in females than male rats and rats that received a 2/3 partial hepatectomy prior to the DENA. The hepatocarcinogenicity of hexachlorobenzene and lindane apparently results from tumor promotion.