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5333244 
Journal Article 
Antagonism Of DDT Storage In Guinea Pigs By Dietary Dieldrin 
Wagstaff, DJ; Street, JC 
1971 
Yes 
Bulletin of Environmental Contamination and Toxicology
ISSN: 0007-4861
EISSN: 1432-0800 
6 
3 
273-278 
English 
4115901 
WOS:A1971J678000013 
The interaction between DDT (50293) and dieldrin (60571) was studied in male Hartley-guinea-pigs. In test 1, DDT, dieldrin and lindane (58899) were fed to guinea-pigs at 25 parts per million (ppm) in the diet. In test 2, guinea-pigs were placed on a diet containing 1ppm dieldrin and 50ppm DDT. An extra group was fed 50ppm dieldrin. In test 3, control guinea-pigs were fed 50ppm DDT in comparison to a group fed a diet containing both 50ppm DDT and 25ppm dieldrin. In all tests, storage of pesticides in peritoneal fat was determined by gas liquid chromatography. Liver microsomal enzyme activity was measured. In test 1, lindane and DDT were stored at low concentrations and only moderately stimulated the activity of liver microsomal enzymes. Dieldrin was stored at a much higher concentration and markedly induced enzyme activity. In test 2, dieldrin storage was unaffected by DDT; however, DDT storage was slightly reduced by concurrent dieldrin exposure. Microsomal enzyme activity was not markedly altered by DDT but was significantly elevated in those animals fed 50ppm dieldrin. A decrease in body weight gain was noted in the animals fed 50ppm dieldrin. In test 3, dieldrin had no effect on body weight gain. Storage of DDT in body fed was reduced 76 percent by concurrent dieldrin consumption. Microsomal enzyme activity was significantly elevated in dieldrin fed animals. The authors conclude that the relationship in dieldrin fed guinea-pigs of increased microsomal enzyme activity and decreased DDT storage suggest that storage may be reduced through stimulated activity of DDT metabolizing enzymes. However, the reduced storage of DDT in guinea-pigs may be due to a species difference in absorption or translocation of the chemical.