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5341711 
Technical Report 
Metabolism-dependent covalent binding of DDT and lindane to cellular macromolecules 
Baker, MT; Carlson, GL; Van Dyke, RA 
1981 
3 
PESTAB. The nature of the in vitro metabolism and binding of 14C-DDT and 14C-lindane to microsomal protein and lipids, and to exogenous DNA, were studied in hepatic microsomes from phenobarbitol-pretreated rats. In incubations containing NADPH, DDT and lindane bound to microsomal proteins and lipids, but not to DNA. DDT binding was enhanced by low O2 concentrations. Lindane binding was inhibited by low O2. The addition of trichloropropane oxide enhanced lindane binding, but inhibited DDT binding. It is suggested that an oxidative pathway may be involved in these processes.