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5341736 
Journal Article 
Sex difference in enhancement of GGTase-positive foci by hexachlorobenzene and lindane in rat liver 
Pereira, MA; Herren, SL; Britt, AL; Khoury, MM 
1982 
Yes 
Cancer Letters
ISSN: 0304-3835
EISSN: 1872-7980 
15 
1 
95-101 
English 
6174209 
The ability of hexachlorobenzene and lindane in diethylnitrosamine (DENA) pretreated rats to enhance the incidence of gamma-glutamyltranspeptidase (GGTase)-positive foci was determined. In rats that received either DENA followed by a basal agar diet or hexachlorobenzene or lindane without prior administration of DENA, the incidence of GGTase-positive foci was negligible. When hexachlorobenzene or lindane were administered in the diet to rats that previously received a 2/3 partial hepatectomy prior to the DENA. The results suggest that hepatocarcinogenicity of hexachlorobenzene and lindane results from tumor promotion.