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5341942 
Technical Report 
Chlorphenamidine as an ovicide and the efficiency of heat in killing lice and nits 
Makara, G 
1973 
Health Organ 
198-200 
PESTAB. The efficacy of chlorphenamidine, an acaricide with an oral LD50 rate of 250, was tested against nits. A 0. 1% solution killed nits within 10 min. The same effect was noted on nits in immersed cloth, although little effect was noted on motile louse stages. After a 30 min exposure to a 0. 5% solution, only about half the lice were killed. Chlorphenamidine can be easily used in combination with lindane, malathion, or other insecticides and incorporated into shampoo, emulsion concentrates, and hair spirits or ointments. It remains stable for one year. Using the shampoo preparation and following a normal washing procedure for about 15 min removed head lice from 97% of 150 persons so treated. In a similar group treated with the conventional combination of lindane and pyrethrum, only a 67% removal was achieved. Irritancy and toxicity of chlorphenamidine are minimal.