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5345750 
Journal Article 
SYNTHESIS OF 2,4-DIFLUOROANILINE AND 1,3-DIFLUOROBENZENE FROM 1,2,4-TRICHLORBENZENE 
Mason, J; Milner, DJ 
1994 
1 
Synthetic Communications
ISSN: 0039-7911 
24 
4 
529-532 
English 
WOS:A1994MZ36900012 
Nitration of inexpensive 1,2,4-trichlorobenzene gave 2,4,5-trichloronitrobenzene (90%) which was treated with KF to form 2,4-difluoro-5-chloronitrobenzene (70%). This was selectively hydrogenated over Pd / C to give 2,4-difluoroaniline (80%). Deamination afforded 1,3-difluorobenzene. The sequence avoids the need for costly 1,3-dichlorobenzene. 
1,3 difluorobenzene; 2,4 difluoroaniline; organofluorine derivative; unclassified drug; article; reaction analysis; synthesis