Health & Environmental Research Online (HERO)


Print Feedback Export to File
5347844 
Journal Article 
One-pot synthesis of quinoline derivatives using choline chloride/tin (II) chloride deep eutectic solvent as a green catalyst 
Shahabi, D; Tavakol, H 
2016 
Yes 
Journal of Molecular Liquids
ISSN: 0167-7322 
220 
324-328 
WOS:000378953900041 
In this work, various quinoline derivatives were prepared efficiently through a one-pot, three component synthesis using choline chloride/tin(II) chloride (ChCl·2SnCl2) deep eutectic solvent (DES) as a green catalyst. The procedure is free of using toxic solvents or catalyst and it could be categorized as a green method. In this procedure, aniline derivatives, aromatic aldehydes and enolizable aldehydes were mixed in the presence of DES that plays both roles of solvent and the reaction catalyst. Using this methodology, quinoline derivatives were synthesized simply at 60 °C in 2-3 h with high yields (54-97%). All products were purified by chromatography and recrystallization in ethanol. The employed DES have been recycled 4 time without important loss of its activity. © 2016 Elsevier B.V. All rights reserved. 
Catalyst; Deep eutectic solvent; Multi-component; Quinolines