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5353065 
Journal Article 
Isomerization of lindane by reduced hematin 
Saleh, MA 
1980 
Yes 
Bulletin of Environmental Contamination and Toxicology
ISSN: 0007-4861
EISSN: 1432-0800 
25 
6 
833-836 
PESTAB. Studies were performed to investigate the isomerization of lindane by reduced hematin. Pure lindane (gamma-HCH) was added to reduced hematin and incubated at 25êC for 72 hr. The products were extracted into hexane, cleaned up by silicic acid column chromatography, and analyzed for products by GC and TLC. Preparative TLC was used to isolate individual HCH (BHC) isomers for identification by NMR. A 0.7% overall yield of a compound matched the TLC chromatograph of the alpha-HCH isomer, but differed from beta-, gamma-, and delta-HCH according to MS analysis. The product also co-chromatographed with alpha-HCH on TLC and gave an NMR spectrum identical to alpha-HCH. The results indicate that lindane is metabolized to alpha-HCH but not to beta-HCH./CONTRAINDICATIONS