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5360990 
Journal Article 
Metabolic drug-drug interaction of chlorphenethazine and chlorpromazine 
Borchert, H; Pfeiffer, S; Bina, B 
1984 
Yes 
Die Pharmazie
ISSN: 0031-7144 
39 
Jan 1984 
IPA COPYRIGHT: ASHP Owing to enzyme induction, the pretreatment of female Wistar rats with chlorphenethazine hydrochloride (Marophen; Elroquil; I) is reported to cause a shortening of the hexobarbital sleeping time and an increase in aminophenazone-N-, codeine phosphate-O- and p-nitroanisole-O-demethylation, a slight stimulation of p-nitrophenol-glucuronidation, but no change in aniline hydroxylation of chlorpromazine hydrochloride (Propaphenin; II) in the 9000 g supernatant of liver homogenates. Comparative studies of I and II showed almost identical inductive activities which were in both cases inferior to that of phenobarbital. It was concluded that the occurrence of I-II interactions cannot be excluded in the framework of combined therapy.