Induction of glutathione S-transferase activity in Norway spruce by xenobiotics and herbicide safeners | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

5372301

Reference Type

Journal Article

Title

Induction of glutathione S-transferase activity in Norway spruce by xenobiotics and herbicide safeners

Author(s)

Schroder, P; Pflugmacher, S

Year

1996

Is Peer Reviewed?

Yes

Journal

Angewandte Botanik
ISSN: 0066-1759

Volume

Issue

3-4

Page Numbers

97-100

Language

English

Web of Science Id

WOS:A1996VL11600001

Abstract

BIOSIS COPYRIGHT: BIOL ABS. The conjugation of CDNB, DCNB, and CH3I with glutathione is significant in protein extracts of Norway spruce (Picea abies L. Karst.) needles and can be attributed to the activity of glutathione S-transferases (GST, E.C. 2.5.1.18). The GST mediated conjugation of the mentioned substrates can be significantly enhanced by donation of xenobiotics and herbicide safeners in concentrations as low as 50 muM. Inductive effects appear to be coupled to the de-novo synthesis of proteins and may be different for GST isozymes. The conjugation of CDNB was stimulated by donations of CDNB, benoxacor or fluxofenim but the conjugation of DCNB was increased by benoxacor, fenclorim and fluxofenim, whereas CDNB was a potent inhibitor of DCNB-GST. Inductions of DCNB conjugation of 800% above controls were obtained with fluxofenim.