US EPA

5372410 

Technical Report 

EXPERIMENTAL CONTACT DERMATITIS IN MICE 

Kawamura, Y; Sonobe, K; Shimizu, M; Hamaguchi, T 

1974 

Yes 

Journal of Dermatology
ISSN: 0385-2407
EISSN: 1346-8138 

83 

3 

83-88 

English 

10.1111/j.1346-8138.1974.tb01068.x 

HEEP COPYRIGHT: BIOL ABS. Pathomorphological and autoradiographic studies indicated that the reaction of mice to sensitization with 1 chlor 2,4-dinitrobenzene (DNCB) was characterized by an increase in epidermal mitotic activity. Sensitization of thymectomized mice, NZB mice, and passive transfer with peritoneal exudate cells demonstrated that this increase in epidermal mitotic activity was dependent upon cell-mediated or delayed hypersensitivity. Although the induction of epidermal changes of eczematous contact dermatitis in mice has been considered difficult, changes such as lymphocytic basal spongiosis could be produced by challenging acanthotic mouse epidermis. Like guinea pigs, mice are useful in experimental contact dermatitis.