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538113 
Journal Article 
Salvia miltiorrhiza Bunge and its active component cryptotanshinone protects primary cultured rat hepatocytes from acute ethanol-induced cytotoxicity and fatty infiltration 
Yin, HQ; Choi, YJ; Kim, YC; Sohn, DH; Ryu, SY; Lee, BH 
2009 
Yes 
Food and Chemical Toxicology
ISSN: 0278-6915
EISSN: 1873-6351 
47 
1 
98-103 
English 
19013495 
WOS:000262775900014 
Alcoholic liver disease involves hepatocellular injury induced by the acute or chronic consumption of ethanol. Fatty infiltration is usually followed by inflammation and focal necrosis, which can lead to cirrhosis if not treated properly in the initial stage. There have been many attempts to develop effective therapies for the disease, using natural products derived from medicinal plants. In this study, we report that the standardized fraction of Salvia miltiorrhiza Bunge (Sm-SF) and its active component, cryptotanshinone, were able to protect hepatocytes from lipopolysaccharide- and ethanol-induced cell death. They also suppressed ethanol-induced lipid accumulation as evidenced by the Nile red binding assay. The ethanol-induced activation and nuclear translocation of sterol regulatory element-binding protein-1 and the consequent transactivation of the target genes involved in fatty acid biosynthesis were inhibited by Sm-SF and cryptotanshinone in a dose-dependent manner. Cryptotanshinone, an active component of S. miltiorrhiza, has the potential to ameliorate alcoholic liver disease by blocking hepatic cell death and fatty acid synthesis. (C) 2008 Elsevier Ltd. All rights reserved. 
Salvia miltiorrhiza; Cryptotanshionone; Primary rat hepatocytes; Alcoholic liver disease; Sterol regulatory element-binding protein-1; tumor-necrosis-factor; alcoholic liver-disease; nitric-oxide synthase; tnf-alpha production; gene-expression; tanshinone-iia; inflammatory; response; induced apoptosis; egr-1 expression; lipid-metabolism