Health & Environmental Research Online (HERO)


Print Feedback Export to File
5414603 
Journal Article 
Novel fluorescent probes of 10-hydroxyevodiamine: autophagy and apoptosis-inducing anticancer mechanisms 
Chen, S; Dong, G; Wu, S; Liu, N; Zhang, W; Sheng, C 
2019 
Acta pharmaceutica Sinica B
ISSN: 2211-3835
EISSN: 2211-3843 
9 
1 
144-156 
English 
30766786 
Natural product evodiamine and its derivatives represent a promising class of multi-target antitumor agents. However, the clinical development of these compounds has been hampered by a poor understanding of their antitumor mechanisms. To tackle this obstacle, herein, novel fluorescent probes were designed to elucidate the antitumor mode of action of 10-hydroxyevodiamine. This compound was proven to be distributed in the mitochondria and lysosomes and to act by autophagy and apoptosis mechanisms. 
PFAS
• PFAS 150
     Literature Search Update December 2020
          PubMed
     Literature Search August 2019
          PubMed
     Not prioritized for screening
     Trifluoroacetic acid