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HERO ID
5424178
Reference Type
Journal Article
Title
Serological and virological evaluation of human T-lymphotropic virus type 1 infection in family groups from Tumaco, Colombia
Author(s)
Dominguez, MC; Salcedo, M; Garcia-Vallejo, F
Year
2015
Is Peer Reviewed?
Yes
Journal
Biomedica
ISSN:
0120-4157
Volume
35
Issue
3
Page Numbers
337-346
Language
English
PMID
26849695
DOI
10.7705/biomedica.v35i3.2601
Web of Science Id
WOS:000364260500007
Abstract
INTRODUCTION:
To date there has been no statistical evaluation of the profiles of immunoglobulin classes and viral replication as variables in the study of HTLV-1 infection and circulation among families in virus-endemic areas of Colombia.
OBJECTIVE:
To evaluate the correlation of several immunological and molecular characteristics with the transmission and circulation of HTLV-1 among families in the town of Tumaco.
MATERIALS AND METHODS:
Plasma levels of HTLV-1 specific immunoglobulin classes IgG, IgM and IgA1, as well as IgG and sIgA in oral fluids, were calculated for 32 members of 10 family groups from Tumaco in which the mother and at least one child were infected with the virus. Levels of the different immunoglobulin classes were correlated with viral RNA circulating in plasma or oral fluids and the proviral burden as detected by RT-PCR.
RESULTS:
Significant differences were determined between mothers and carrier children for immunoglobulin levels (p=0.037) and proviral burden (p=0.002). The overall estimate of IgG in plasma and sIgA in oral fluids could be correlated with the circulation of free viral RNA in both fluids and high proviral burden, and associated with HAM/TSP mothers. The detection of anti- tax IgG in plasma revealed differences between HAM/TSP mothers and their offspring.
CONCLUSION:
The study of immunological and molecular variables permitted the analysis of HTLV-1 circulation among families of Tumaco. The strong correlation between levels of IgM specific for the virus and viral RNA circulating in fluids indirectly confirmed the transmission of HTLV-1 among families.
Keywords
Human T-lymphotropic virus; molecular epidemiology; infection; virological analysis; immunoglobulins
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