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HERO ID
5428336
Reference Type
Journal Article
Title
Synthetic musks in blood of healthy young adults: relationship to cosmetics use
Author(s)
Hutter, HP; Wallner, P; Moshammer, H; Hartl, W; Sattelberger, R; Lorbeer, G; Kundi, M
Year
2009
Is Peer Reviewed?
1
Journal
Science of the Total Environment
ISSN:
0048-9697
EISSN:
1879-1026
Publisher
Elsevier
Volume
407
Issue
17
Page Numbers
4821-4825
Language
English
PMID
19520417
DOI
10.1016/j.scitotenv.2009.05.026
Web of Science Id
WOS:000268371500005
URL
https://linkinghub.elsevier.com/retrieve/pii/S0048969709005002
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Abstract
Production of polycyclic musk compounds is increasing accompanied by a decline in nitro musk production. Although it can be assumed that due to this reduction nitro musks are less prevalent in human body fluids, there are no data available from the last decade. This study examined the concentrations of five nitro musks and six polycyclic musks in blood samples from young healthy volunteers. Blood was taken from 100 healthy students of the Medical University of Vienna. The lipophilic fraction was extracted and after purification analyzed by GC-MS. Study participants also completed a questionnaire on the use of cosmetics, about nutrition and other life-style aspects. Highest percentages of synthetic musks in blood plasma samples were found for galaxolide (91%, median 420 ng L(-1)) and musk xylene (79%, median 11 ng L(-1)). Both musk ketone and tonalide were found in 17%. In two cases musk ambrette was detected. In a multivariate approach only younger age, use of lotion and perfumes did significantly predict blood concentrations of polycyclic musks. For nitro musks except body surface area no significant predictor could be found. High percentage of the population is still exposed to nitro musk compounds although blood concentrations of nitro musks are generally lower than those of polycyclic musks. Compared to earlier investigations performed in the 1990s nitro musks were detected in lower percentages and concentrations. There seems to be no dominant source of nitro musk uptake although relationship to body surface area indicates cosmetic products applied to the skin as the likely origin of plasma concentrations.
Keywords
Synthetic musks; Nitro musks; Polycyclic musks; Human blood
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