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HERO ID
5433188
Reference Type
Journal Article
Title
A strategy to validate a selection of human effect biomarkers using adverse outcome pathways: Proof of concept for phthalates and reproductive effects
Author(s)
Baken, KA; Lambrechts, N; Remy, S; Mustieles, V; Rodríguez-Carrillo, A; Neophytou, CM; Olea, N; Schoeters, G
Year
2019
Is Peer Reviewed?
Yes
Journal
Environmental Research
ISSN:
0013-9351
EISSN:
1096-0953
Volume
175
Page Numbers
235-256
Language
English
PMID
31146096
DOI
10.1016/j.envres.2019.05.013
Web of Science Id
WOS:000473836300025
Abstract
Human biomonitoring measures the concentrations of environmental chemicals or their metabolites in body fluids or tissues. Complementing exposure biomarkers with mechanistically based effect biomarkers may further elucidate causal pathways between chemical exposure and adverse health outcomes. We combined information on effect biomarkers previously implemented in human observational studies with mechanisms of action reported in experimental studies and with information from published Adverse Outcome Pathways (AOPs), focusing on adverse reproductive effects of phthalate exposure. Phthalates constitute a group of chemicals that are ubiquitous in consumer products and have been related to a wide range of adverse health effects. As a result of a comprehensive literature search, we present an overview of effect biomarkers for reproductive toxicity that are substantiated by mechanistic information. The activation of several receptors, such as PPARα, PPARγ, and GR, may initiate events leading to impaired male and female fertility as well as other adverse effects of phthalate exposure. Therefore, these receptors appear as promising targets for the development of novel effect biomarkers. The proposed strategy connects the fields of epidemiology and toxicology and may strengthen the weight of evidence in observational studies that link chemical exposures to health outcomes.
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