Health & Environmental Research Online (HERO)


Print Feedback Export to File
5433754 
Journal Article 
A new synthesis of cis-cyclobut-3-ene-1,2-dicarboxylic anhydride 
Gauvry, N; Comoy, C; Lescop, C; Huet, F 
1999 
1 
Synthesis
ISSN: 0039-7881
EISSN: 1437-210X 
4 
574-576 
WOS:000079684400007 
The title compound was prepared in two steps by [2+2] photochemical cycloaddition between (E)-1,2-dichloroethene and maleic anhydride followed by reductive chlorine elimination with activated zinc. This safe synthetic route gave cis-cyclobut-3-ene-1,2-dicarboxylic anhydride in good overall yield and could be carried out on a multigram scale. 
cyclobutenes; photochemistry; [2+2] cycloaddition; reduction; activated zinc